越来越多的研究表明中药、肠道菌群和宿主健康之间存在着紧密的联系，近年来有关中药和肠道菌群相互作用的研究为探索中药在多种疾病中的作用机制提供了新的视角。主要通过探讨中药-肠道菌群相互作用与宿主自身代谢免疫稳态相关性的研究进展，回顾了中药对肠道菌群组成结构及其代谢产物的影响、肠道菌群与中药“构-效关系”的相关性研究，同时对现有研究的不足之处及未来展望进行总结，以期为科研工作者提供一定的科研借鉴。

A growing number of studies suggests that there is a tight relationship among traditional Chinese medicine (TCM), gut microbiota and host health. Recent research on interaction between TCM and gut microbiota have provided a novel insight into the mechanistic functions of TCM in various diseases. Research progress on correlation of TCM-gut microbiota and the host’s own immune homeostasis were reviewed in this paper. The effects of TCM on composition and metabolites of gut microbiota, and the correlation between gut microbiota and structure-activity relationship of TCM were reviewed. In the end, the shortcomings of existing research and future prospect were pointed out, in order to provide some reference for researchers.

R282.710.5

国家自然科学基金青年项目（31900103）；澳门科学技术发展基金项目（FDCT 0054-2018-A2）；佛山市医学登峰计划（2019-2021）