[关键词]
[摘要]
糖尿病是一种由于体内胰岛素绝对或相对分泌不足而引起的以糖代谢紊乱为主的全身性疾病,严重威胁人类的身心健康,而中国和东盟地区更是糖尿病高发地区,患病人数居全球第1位。通过查阅《中国-东盟传统药物志》,中国和东盟国家用于治疗糖尿病、消渴症的传统药物有81种,其中在中国和东盟国家中应用较为广泛且研究较为深入的有25种。利用中国知网、维普、Pubmed等数据库系统地查阅和整理国内外关于25种传统药物治疗糖尿病及其并发症的相关文献,对25种药物降血糖药理作用及其作用机制进行综述,传统药物改善糖尿病及其并发症的作用机制主要是通过抑制炎症及过氧化反应,调节糖脂,改善胰岛素抵抗,提高胰岛素敏感性,修复胰岛细胞,促进胰岛素分泌等途径,可为开发安全、有效的降糖药以及加强中国和东盟国家进一步的研究合作提供有益的参考。
[Key word]
[Abstract]
Diabetes is a systemic disease due to insufficient or relative secretion of insulin in the body, which leads to glucose metabolism disorder. It seriously threatens the physical and mental health of human beings. China and ASEAN are both high-risk regions of diabetes, with the top 1 patients in the world. By reviewing the book China-ASEAN Traditional Medicine, 81 spieces of traditional medicines can be used to treat diabetes and Xiaoke in China and ASEAN countries, and 25 types that are widely used and studied in depth in China and ASEAN countries. CNKI, Vip, Pubmed and other databases are systematically searched and domestic and foreign literatures about 25 species of traditional medicines for the treatment of diabetes and its complications are organized in this paper. By reviewing the pharmacological effects of 25 species of traditional medicine and their mechanism of action, traditional medicines to improve the mechanism of diabetes and its complications are mainly through inhibiting inflammation and peroxidation, regulating glycolipids, improving insulin resistance, improving insulin sensitivity, repairing islet cells and promoting insulin secretion and so on, which can provide some useful references for development of safe and effective hypoglycemic agents and strengthening the further research cooperation between China and ASEAN countries.
[中图分类号]
R286.7
[基金项目]
中国-东盟传统药物研究国际合作联合实验室建设(二期);广西科技基地和人才专项(桂科AD19110155)