[关键词]
[摘要]
靶向制剂亦称靶向给药系统,将药物浓集于病变部位,并使药物保持一定浓度在靶部位滞留一定的时间,从而减少用药剂量,在一定程度上可减少药物不良反应的发生,提高药物的安全性和患者用药的顺应性,故靶向制剂在药剂学领域受到广泛的关注。对近年来中药靶向制剂应用的相关研究进行综述,主要从中药被动靶向、主动靶向和物理化学靶向3个方面阐述中药靶向给药的研究进展,以期为靶向制剂技术在中药靶向制剂中的应用研究提供参考。
[Key word]
[Abstract]
Targeted preparations are also called targeted drug delivery systems, which concentrate the drug on the lesion and keep the drug at a certain concentration for a period of time at the target site, thereby reducing the dosage. To a certain extent, they can reduce the occurrence of adverse drug reactions and improve the safety of drugs and the compliance of patients with medication. Therefore, targeted preparations are widely concerned in the field of pharmacy. The related research on the application of Chinese medicine targeted preparations in recent years are reviewed in this article. The research progress on targeted preparations of traditional Chinese medicine is described from three aspects of passively targeted formulations, active targeted formulations, physical and chemical targeted formulations of traditional Chinese medicine, aiming to provide a reference for the application research of targeted preparation technology in Chinese medicine targeted preparations.
[中图分类号]
R283.3
[基金项目]
国家重点研发计划项目(2018YFC170810203);重大新药创制专项(2019ZX09201-005)