[关键词]
[摘要]
目的 对多穗金粟兰Chloranthus multistachys中倍半萜类化学成分进行研究。方法 利用多种色谱方法进行分离纯化,然后利用1D-NMR、2D-NMR、单晶X射线衍射等方法进行结构鉴定。结果 从多穗金粟兰二氯甲烷部位中分离得到10个倍半萜类化合物,分别鉴定为(1R,4R,5R,8S,10R)-1-羟基-4-乙氧基桉叶-7(11)-烯-12,8-内酯(1a)、(1S,4S,5S,8R,10S)-1-羟基-4-乙氧基桉叶-7(11)-烯-12,8-内酯(1b)、(9S,10S)-(-)-9β-hydroxycyclocolorenon(2)、myrrhterpenoid N(3)、1α,8α,9α-三羟基桉叶-3(4),7(11)-二烯-8β,12-内酯(4)、dihydrocurcolone(5)、curvularin(6)、neolitacumone A(7)、银线草内酯F(8)和苍术内酯Ⅲ(9)。结论 其中化合物1a和1b为1对新的倍半萜对映异构体,分别命名为(+)-多穗金粟兰内酯M和(-)-多穗金粟兰内酯M;化合物2为1个新的天然产物,化合物3~6为首次从该属植物中分离得到,其余化合物均为首次从该植物中分离得到。
[Key word]
[Abstract]
Objective To study the sesquiterpenoids from Chloranthus multistachys. Methods A variety of chromatographic methods were used for the separation and purification, and then the structures were identified by 1D-NMR, 2D-NMR and Single-crystal X-ray diffraction. Results A total of 10 sesquiterpenoids were isolated from dichloromethane fraction of C. multistachys and identified as (1R,4R,5R,8S,10R)-1-hydroxy-4-ethoxyeudesm-7(11)-en-12,8-olide (1a), (1S,4S,5S,8R,10S)-1-hydroxy-4-ethoxyeudesm-7(11)-en-12,8-olide (1b), (9S,10S)-(-)-9β-hydroxycyclocolorenon (2), myrrhterpenoid N (3), 1α,8α,9α-trihydroxyeudesman-3(4),7(11)-dien-8β,12-olide (4), dihydrocurcolone (5), curvularin (6), neolitacumone A (7), shizukanolide F (8), and atractylenolid Ⅲ (9). Conclusion Compounds 1a and 1b are a new pair of sesquiterpene enantiomers, compound 2 is a new natural product, compounds 3-6 are isolated from this genus for the first time, and other compounds are isolated from this plant for the first time.
[中图分类号]
R284.1
[基金项目]
国家自然科学基金资助项目(82060697);江西省“赣鄱英才555工程”项目;江西中医药大学博士科研启动基金(2018BSZR003)