目的 对射干麻黄汤化裁治疗小儿咳嗽变异性哮喘（CVA）进行的Meta分析。方法 对中国知网、中国生物医学文献数据库、维普数据库、万方数据库、PubMed、Embase和Cochrane Library这7类数据库中射干麻黄汤化裁治疗小儿CVA相关的随机对照试验（randomized controlled trial，RCT）进行检索和搜集，检索时限为建库至2020年4月1日。2名研究者根据纳入与排除标准独立地进行文献筛选、资料提取及文献的方法学质量评价，并采用RevMan 5.3软件进行Meta分析。结果 最终共纳入17个RCT，包括1661例患者。Meta分析结果显示，试验组的有效率[OR=5.67，95% CI（4.20，7.65），P<0.000 01] 优于对照组，且试验组嗜睡[OR=0.13，95% CI（0.04，0.51），P=0.003]、皮疹[OR=0.14，95% CI（0.04，0.47），P=0.002]、胃肠道不适[OR=0.16，95% CI（0.05，0.51），P=0.002] 等不良反应发生较少。结论 射干麻黄汤化裁治疗小儿CVA具有较好的临床疗效和安全性。

Objective To evaluate the efficacy of modified Shegan Mahuang Decoction (射干麻黄汤) in treating children with cough variant asthma (CVA). Methods The literatures were searched from CNKI, CBM, VIP, Wanfang Database, PubMed, EMbase and Cochrane Library up to April 1, 2020. The randomized controlled trials (RCTs) of modified Shegan Mahuang Decoction for the treatment of CVA in children were included. Two reviewers independently extracted data and assessed the methodological quality of included studies. RevMan 5.3 software was employed for Meta-analysis. Results A total of 17 RCTs involving 1661 patients were included. Meta-analysis indicated that modified Shegan Mahuang Decoction showed significant benefits in increasing the overall effectiveness[OR=5.67, 95% CI (4.20, 7.65), P < 0.000 01], reducing drowsiness[OR=0.13, 95% CI (0.04, 0.51), P=0.003], rash[OR=0.14, 95% CI (0.04, 0.47), P=0.002] and gastrointestinal discomfort[OR=0.16, 95% CI (0.05, 0.51), P=0.002]. Conclusion Modified Shegan Mahuang Decoction has a good and safe clinical effect in treating the children with CVA.

R285.64

江苏高校优势学科建设工程（中西医结合）