[关键词]
[摘要]
近年来,细菌耐药性已经发展成为一个全球性的问题,以临床常见耐药细菌及其天然抗生素增效剂为研究对象,通过查阅国内外相关文献,对国内外各种天然产物与临床中常使用的抗生素联合使用以降低各种细菌的耐药性及产生作用的机制等进行归纳、分析,总结了临床中常见的耐药细菌及降低其耐药性的天然抗生素增效剂的相关研究。研究表明,天然产物由于其结构的复杂性和新颖性,可作为抗生素增效剂,为降低各种细菌的耐药性以及为临床治疗各种病菌引起的感染提供治疗思路。
[Key word]
[Abstract]
In recent years, drug-resistant bacteria have developed into a global problem. Common clinically resistant bacteria and their natural antibiotic synergists are the objects of research in this paper. Through consulting the relevant literature at home and abroad, the combination of various natural products and antibiotics commonly used in clinic to reduce the various bacterial drug resistance and the mechanism of action are summarized and analyzed. The related studies on the common drug-resistant bacteria in clinical practice and the natural antibiotic synergists to reduce their resistance were summarized in this paper. The results show that natural products can be used as antibiotic synergists due to their structural complexity and novelty, which provides new ideas and methods for clinical treatment of drug-resistant bacterial infections.
[中图分类号]
R286.81
[基金项目]
陕西省中医药管理局第四次“全国中药资源普查”项目(财社[2018]43号);2020年陕西省重点研发计划项目(2020ZDLSF05-05);陕西省中医药优秀中青年科技骨干人才