In recent years, drug-resistant bacteria have developed into a global problem. Common clinically resistant bacteria and their natural antibiotic synergists are the objects of research in this paper. Through consulting the relevant literature at home and abroad, the combination of various natural products and antibiotics commonly used in clinic to reduce the various bacterial drug resistance and the mechanism of action are summarized and analyzed. The related studies on the common drug-resistant bacteria in clinical practice and the natural antibiotic synergists to reduce their resistance were summarized in this paper. The results show that natural products can be used as antibiotic synergists due to their structural complexity and novelty, which provides new ideas and methods for clinical treatment of drug-resistant bacterial infections.