液液分配色谱（liquid-liquid partition chromatography，LLC）是一种连续高效的分配色谱技术，如今已广泛应用于天然产物领域。天然花色苷是一种黄酮类天然色素，具有多种生理活性。花色苷极不稳定，LLC因其具有操作条件温和、可避免样品不可逆吸附等特点目前已广泛应用于天然花色苷的制备性分离。综述了2010—2019年LLC及其与液相色谱联用（liquid-liquid partition chromatography-liquid chromatography，LLC-LC）分离纯化天然花色苷的研究进展。

Liquid-liquid partition chromatography (LLC) is a continuous and efficient chromatography technique now widely used in the field of natural products. Natural anthocyanin is a flavonoid natural pigment with many physiological activities. Anthocyanin is very unstable and LLC has been widely used in the separation of natural anthocyanin because of its mild operating conditions and the avoidance of irreversible adsorption of samples. The research progress on separation of natural anthocyanin by LLC and combination with liquid chromatography from 2010 to 2019 is reviewed in this paper.

R284.13

国家自然科学基金资助项目（21978266）