豨桐丸最早记载于乾隆五十六年（1791年）毛世洪的《济世养生集》中，具有清热燥湿、疏风止痛的功效，适用于风湿热痹，临床常用于治疗痛风、风湿性关节炎等疾病。豨桐丸仅有豨莶草和臭梧桐2味中药组成，因其药简力专、配伍精当、疗效突出等特点，既可单独使用也可与其他经典方剂合方使用，临床应用十分广泛。通过查阅本草古籍和现代国内外文献，对豨桐丸其组方药物进行本草考证，梳理其历史沿革及临床应用情况，并对其化学成分和现代药理作用研究进展进行归纳分析，以期为豨桐丸的现代临床应用及药理作用机制的深入研究提供参考。

As one of classical prescriptions, Xitong Pill was first recorded in Shihong Mao's "Ji Shi Yang Sheng Ji" in the fifty-sixth year of Emperor Qianlong (1791), with the functions of clearing heat, eliminating dampness, dispelling wind and relieving pain, to treat wind-damp-heat arthralgia syndrome, which clinically contains gout, rheumatoid arthritis and other diseases. Xitong Pill, as the Chinese Medicine prescription, is only consisted of two herbs, Siegesbeckia and Clerodendrum trichotomum, and widely used in clinic alone or combined with other classic prescriptions due to its precisely compatibility and significant curative effects. In this paper, herbological study and clinical application of Xitong Pill were reviewed, as well as research progresses of main chemical constituents and pharmacological activities of herbs in the formula, by analyzing ancient Chinese herbal medicine books and modern literatures, in order to provide a reference of Xitong Pill for clinical applications and further research on its pharmacological mechanisms.

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