[关键词]
[摘要]
优良的服药口感对于保障中医临床疗效具有重要意义。针对中药粉末制剂的服用弊端及儿童、老人等特殊人群的服药需求,受酸枣麨、龙角散与冻干泡沫剂型特点的启发,基于对中药粉体结构-性质-功能的认识,综合中药粉体改性技术、中药矫味技术与原料药前处理技术,提出了一种新型递药形式——中药口腔速溶散。对中药口腔速溶散的概念、基本特点、原辅料组成、设计原理、工艺路线、核心设备、质量评价、技术优势及应用前景等内容进行系统解析,期待中药口腔速溶散的研制开发能更好地保障特殊人群的服药便利性,为中医临床提供“良药可口”的新选择,为粉末饮片、医院制剂、中成药散剂在新时代的升级发展提供新的思路与技术。
[Key word]
[Abstract]
Excellent taste is of great significance to ensure the clinical efficacy of traditional Chinese medicine. Aiming at the deficiency of traditional Chinese medicine powder preparation and the demand of children and elderly people with insufficient swallowing function, a novel dosage form called Chinese medicine oral instant powders was proposed. The introduction of this concept was inspired by the characteristics of ancient Jujube Instant Beverage, Longjiao Powders from Japan and freeze-dried tablets. It was also based on the understanding of the structure-property-function of traditional Chinese medicine powder, and integrated powder modification technology, taste masking technology, and the pretreatment technology of raw materials. In this manuscript, the concept, basic characteristics, composition of raw materials and accessories, design principle, process route, core equipment, quality evaluation methods and technical advantages of Chinese medicine oral instant powders were introduced in detail. It is hoped that the development of Chinese medicine oral instant powders will help to meet the needs of special population. Meanwhile, it will provide new ideas and technologies for the innovation of powder decoctions, hospital preparations and Chinese patent medicine powders in new era.
[中图分类号]
[基金项目]
国家自然科学基金资助项目(81803745);四川省科技厅青年杰出科技人才资助项目(2019JDJQ0007);四川省中医药管理局科研创新专项(2018YY005);成都市科技局技术创新研发项目(2018-YFYF-00060-SN);成都中医药大学“杏林学者”学科人才科研提升计划(BSH2018007);江西中医药大学现代中药制剂教育部重点实验室开放基金(TCM-201904)