Excellent taste is of great significance to ensure the clinical efficacy of traditional Chinese medicine. Aiming at the deficiency of traditional Chinese medicine powder preparation and the demand of children and elderly people with insufficient swallowing function, a novel dosage form called Chinese medicine oral instant powders was proposed. The introduction of this concept was inspired by the characteristics of ancient Jujube Instant Beverage, Longjiao Powders from Japan and freeze-dried tablets. It was also based on the understanding of the structure-property-function of traditional Chinese medicine powder, and integrated powder modification technology, taste masking technology, and the pretreatment technology of raw materials. In this manuscript, the concept, basic characteristics, composition of raw materials and accessories, design principle, process route, core equipment, quality evaluation methods and technical advantages of Chinese medicine oral instant powders were introduced in detail. It is hoped that the development of Chinese medicine oral instant powders will help to meet the needs of special population. Meanwhile, it will provide new ideas and technologies for the innovation of powder decoctions, hospital preparations and Chinese patent medicine powders in new era.