目前，国内外对中药物质基础的研究方法主要有植化分离法、药理活性示踪法、色谱法等，上述方法为阐明中药物质基础起到了积极作用。然而，如何形成一套既能较好的体现中药“整体观”特色，又能反映中药发挥药效的多成分特点研究模式，已成为业内学者探索的重要方向。中药血清谱效学是在谱效理论研究基础上，以体内血清化学指纹图谱及相应的药效学开展的中药物质基础研究。通过查阅相关文献，对中药血清谱效学的研究思路进行抽提，对其研究成果进行统计，对中药血清谱效学的研究瓶颈进行剖析和探讨，以期为更好地揭示中药发挥药效的实质提供参考和借鉴。通过查阅相关文献，对中药血清谱效学的研究思路进行抽提，对其研究成果进行统计，对中药血清谱效学的研究瓶颈进行剖析和探讨，以期为更好地揭示中药发挥药效的实质提供参考和借鉴。

Currently, the domestic and foreign research methods for the qualitative basis of Chinese materia medica (CMM) mainly include phytochemical separation method, pharmacological activity tracer method, chromatography, etc. The above methods have played an active role in elucidating the qualitative basis of CMM. However, how to form a multi-component research model that can better reflect the "holistic view" characteristics of CMM and reflect the effectiveness of CMM has become an important direction for scholars in the industry to explore. Serum spectrum-effect of CMM is based on the theory of spectrum-effect to study the relationship between serum chemical fingerprints and pharmacodynamics in vivo. In this paper, by consulting relevant literature, the research idea of serum spectrum-effect was collected, the research results were summarized, and the research bottleneck was analyzed and discussed, so as to provide reference for revealing the material basis of CMM.

国家自然科学基金资助项目（81673618）