[关键词]
[摘要]
目的 研究没药属没药Commiphora myrrha的倍半萜类化学成分。方法 采用硅胶、Sephadex LH-20、ODS等多种柱色谱,结合制备液相等方法进行分离和纯化,根据理化性质及波谱数据对化学成分进行结构鉴定。结果 从没药二氯甲烷提取物中分离得到10个倍半萜类化合物,分别鉴定为11-methoxyl-guaia-6,10-dien-4α-ol (1)、(1R,4S,5R,10R)-isodauc-6-en-10,14-diol (2)、10α-hydroxy-isodauc-6-en-14-al (3)、guaia-6,10-dien-4α,11-diol (4)、orientalol B (5)、(1S,4R,5R,10S)-isodauc-6-en-10,14-diol (6)、(1S,4S,5R,10S)-isodauc-6-en-10,14-diol (7)、alismanoid C (8)、guaiandiol (9)、canangaterpene VI (10)。结论 化合物1为新化合物,命名为没药醇A。化合物2~10均为首次从该属植物中分离得到。
[Key word]
[Abstract]
Objective To study the chemical constituents from Myrrha. Methods The compounds were isolated and purified by column chromatography over silica gel, Sephadex LH-20, RP-ODS and preparative RP-HPLC. Their structures were elucidated by physicochemical properties and spectral analyses. Results Ten sesquiterpenes were isolated and identified as 11-methoxyl- guaia-6,10-dien-4α-ol (1), (1R,4S,5R,10R)-isodauc-6-en-10,14-diol (2), 10α-hydroxy-isodauc-6-en-14-al (3), guaia-6,10-dien- 4α,11-diol (4), orientalol B (5), (1S,4R,5R,10S)-isodauc-6-en-10,14-diol (6), (1S,4S,5R,10S)- isodauc-6-en-10,14-diol (7), alismanoid C (8), guaiandiol (9) and canangaterpene VI (10). Conclusion Compound 1 is a new compound, named as commiphorol A and compounds 2-10 are isolated from the genus for the first time.
[中图分类号]
R284.1
[基金项目]
国家重点研发计划资助(2019YFC1711000);西青区鼓励高端制造创新驱动发展项目(cgzh-cgk-201801)