中药炮制是一项传统的制药技术，是连接中医学和中药学的关键点。经过加工炮制以后的中药材发生了复杂的化学变化，这些物质发生的化学变化正是导致中药炮制前后性味功能改变的重要原因。制约中药现代化发展的一个关键因素就是中药质量控制，也一直是社会和中医药界研究的热点。2016年，刘昌孝院士首次提出了"质量标志物（Q-marker）"的新概念，引起了中医界的热烈讨论。将中药"质量标志物"的研究思路与加工炮制相结合，阐明中药炮制过程中化学成分发生的变化，形成具有体现中药炮制特点的质量控制的新思路，有利于加快中药加工炮制质量控制方法的发展与完善。

As a traditional pharmacy technology, Chinese materia medica processing is the key link between traditional Chinese medicine and Chinese pharmacy. Some complex chemical changes occur in the processed Chinese medicinal materials, and the chemical changes in these materials are the significant causes leading to the changes in the nature and flavor of medicines before and after processing. A key restraint factor of the modernization of Chinese materia medica is the quality control of Chinese materia medica, which has always been a research focus in sociology and traditional Chinese medicine field. A new concept of "Q-marker" was first put forward by academician Chang-xiao Liu in 2016, which prompted a heated discussion in the Chinese medicine community field. Combining the research thinking "Q-marker" with Chinese materia medica processing, clarifying chemical composition changes during Chinese materia medica processing, and forming a new idea of quality control with the characteristic of Chinese materia medica processing are beneficial to accelerate the development and perfection of quality control methods for Chinese materia medica processing.

国家自然科学基金项目（81803653）；天津市重点研发计划——科技支撑重点项目（19YFZCSY00170，19YFZCSN00010）；大学生创新创业训练计划（201910069007，201910069102）