目的 研究珠芽景天Sedum bulbiferum全草的化学成分。方法 综合运用D101大孔树脂柱色谱、反复硅胶柱色谱、Sephadex LH-20凝胶柱色谱等色谱技术进行分离，并运用MS、NMR技术对分离得到的化合物进行结构鉴定。结果 从珠芽景天全草70%乙醇提取物中分离得到13个化合物，分别鉴定为4-羟基-3-甲氧基苯基-β-D-吡喃葡萄糖苷（1）、丁香酸葡萄糖苷（2）、2-（3，4-二甲氧基苯基）甲基-β-D-葡萄糖苷（3）、橄榄树脂素（4）、环橄榄树脂素-9-O-β-D-吡喃葡萄糖苷（5）、（-）-橄榄树脂素9'-O-β-D-吡喃葡萄糖苷（6）、（-）-二氢去氢二松柏醇-9-O-β-D-吡喃葡萄糖苷（7）、bluemenol A（8）、euodionoside D（9）、脑苷酯B（10）、腺苷（11）、尿苷（12）、4-（β-D-glucopyranosyloxy）-3-hydroxy-2-（hydroxymethyl）-butanenitrile（13）。结论 所有化合物均首次从珠芽景天中分离得到，其中化合物1～5，8～13为首次从景天属植物中分离得到。

Objective To study the chemical constituents of Sedum bulbiferum. Methods The compounds were isolated and purified by a variety of chromatographic techniques, including D-101 macroporous adsorptive resins, silica gel, Sephadex LH-20, and other methods. Their structures were identified by the MS, NMR. Results A total of 13 compounds were isolated and identified from 70% ethanol fraction of the plant, which were 4-hydroxy-3-methoxyphenyl-β-D-glucopyranoside (1), glucosyringic acid (2), 2-(3,4-methoxyphenyl)-methyl-β-D-glucopyranoside (3), olivil (4), cycloolivil-9-O-β-D-glucopyranoside (5), (-)-olivil-9'-O-β-D- glucopyranoside (6), (-)-dihydrodehydrodiconiferylalcohol 9-O-β-D-glucopyranoside (7), bluemenol A (8), euodionoside D (9), cerebroside B (10), adenosine (11), uridine (12), 4-(β-D-glucopyranosyloxy)-3-hydroxy-2-(hydroxylmethyl)-butanenitrile (13). Conclusion All compounds are isolated from S. bulbiferum for the first time. Compounds 1-5, and 8-13 are obtained from the genus Sedum for the first time.

R284.1

国家自然科学基金项目（U1812403）；贵州省创新人才团队项目（20165613/5677）；中央引导地方科技专项项目（20184006）