目的 研究狼毒大戟Euphorbia fischeriana根部的化学成分。方法 采用硅胶、ODS、Sephadex LH-20以及制备HPLC等方法进行分离纯化，根据理化性质及核磁共振波谱数据鉴定化合物的结构。结果 从狼毒大戟95%乙醇提取物中分离得到14个化合物，分别鉴定为秦皮素（1）、莨菪亭（2）、反式-3-（3-羟基苯基）-丙烯酸（3）、阿魏酸（4）、和厚朴新酚（5）、3，3'-二甲基鞣花酸（6）、（3R，4S）-3-methyl-3，4-dihydro-5，6，7-trihydroxy-4-（3'-methoxy-4'-hydroxyphenyl）-1H-[2]-benzopyran-1-one（7）、异落叶松树脂醇-9-O-β-D-吡喃葡萄糖（8）、吲哚-3-甲醛（9）、苯基-β-萘胺（10）、4-epi-15-hydroxyacorenone（11）、巴卡亭（12）、24-methylenecycloartane-3，28-diol（13）和β-谷甾醇（14）。结论 化合物3、5、7～11为首次从大戟属植物中分离得到，化合物1、4、6、12为首次从该植物中分离得到。

Objective To investigate the chemical constitutes from the roots of Euphorbia fischeriana. Methods Compounds were isolated and purified by a combination of various chromatographic techniques including silica gel, ODS, Sephadex LH-20 gel, and preparative HPLC methods. Their structures were elucidated by physiochemical property and NMR analysis. Results Fourteen compounds were obtained from 95% ethanol extract of the roots of E. fischeriana and identified as fraxidin (1), scopoletin (2), trans-3-hydroxycinnamoyl acid (3), (E)-ferulic acid (4), obovatol (5), 3,3'-di-O-methylellagic acid (6), (3R,4S)-3-methyl-3,4- dihydro-5,6,7-trihydroxy-4-(3'-methoxy-4'-hydroxyphenyl)-1H-[2]-benzopyran-1-one (7), iso-lariciresinol-9-O-β-D-glucopyranoside (8), indole-3-aldehyde (9), phenyl-β-naphthylamine (10), 4-epi-15-hydroxyacorenone (11), baccatin (12), 24-methylenecycloartane- 3,28-diol (13), and β-sitosterol (14), respectively. Conclusion Compounds 3, 5, 7-11 are isolated from the genus Euphorbia for the first time. Compounds 1, 4, 6, 12 are isolated from E. fischeriana for the first time.

R284.1

国家自然科学基金资助项目（81872761）；北京市科委G20工程医药产业创新研发项目（Z181100002218029）；中国医学科学院中央高校基本科研业务费项目（3332019117）；新疆生产建设兵团塔里木盆地生物资源保护利用重点实验室开放课题（BRZD1704）