目的 对地椒Thymus quinquecostatus化学成分进行研究，以期发现新化合物。方法 采用色谱硅胶、AB-8大孔树脂、Sephadex LH-20凝胶色谱、ODS反相色谱等多种技术进行分离纯化，运用质谱、核磁共振谱等方法进行化合物结构鉴定。结果 从地椒醋酸乙酯部位分离得到2个化合物，分别鉴定为6-羟基-11-甲基-12-羟甲基萘并[2，3-β]呋喃-1，4-二酮（1）、2-羟基-4-异丙基-5-甲基苯-O-β-D-葡萄糖苷（2）。结论 化合物1、2为新化合物，分别命名为地椒醌A、地椒苷A。

Objective To study the chemical components of Thymus quinquecostatus in order to find new compounds. Methods The constituents were separated by column chromatographic methods of silica gel, AB-8 resin, Sephadex LH-20 and ODS column. The structures were elucidated by MS and NMR analyses. Results Two compounds were isolated and identified as 6-hydroxy-11-methyl-12-hydroxymethyl naphtho[2,3-β] furan-1,4-dione (1) and 2-hydroxy-4-isopropyl-5-methylbenzene-O-β-D-glucopyranoside (2). Conclusion Compounds 1 and 2 are new compounds, named quinquequinone A and quinqueside A, respectively.

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国家自然科学基金资助项目（81760769）；宁夏回族自治区重点研发计划（2018BEG03016）；北京中医药大学青年教师项目（1000061222118）