目的 研究云南沉香Aquilaria yunnanensis果壳的化学成分。方法 采用硅胶、Sephadex LH-20柱色谱和半制备HPLC技术进行分离、纯化，结合理化性质和波谱数据鉴定化合物的结构。结果 从云南沉香果壳的95%乙醇提取物的醋酸乙酯萃取部位中分离得到13个化合物，分别鉴定为trans-linalool-3，6-oxide-7-O-β-D-（6'-O-acetyl）-glucoside（1）、苯乙基-8-O-β-D-（6'-O-乙酰基）-葡萄糖苷（2）、芒果苷（3）、鸢尾酚酮-3，5-C-β-D-二葡萄糖苷（4）、山柰酚-3-O-β-D-葡萄糖苷（5）、木犀草素-7-O-β-D-葡萄糖苷（6）、异鼠李素-3-O-β-D-葡萄糖苷（7）、山柰酚-3-O-β-D-（6''-对-香豆酰基）-葡萄糖苷（8）、香叶醇-1-O-β-D-葡萄糖苷（9）、3-[2-甲酰基-5-（羟甲基）-1H-吡咯-1-基]戊二酸（10）、大麻酰胺D（11）、淫羊藿次苷D₂（12）、松柏苷（13）。结论 化合物1为新的单萜苷类化合物，命名为云南沉香苷C，化合物2为新天然产物，7、9～13为首次从沉香属植物中分离得到，所有化合物均为首次从该植物中分离得到。

Objective To investigate the chemical constituents from the pericarps of Aquilaria yunnanensis. Methods The chemical constituents were separated and purified by silica gel, Sephadex LH-20 column chromatography, and semi-preparative HPLC. The structures of isolated compounds were identified by physicochemical properties and spectroscopic data. Results Thirteen compounds were isolated from the ethyl acetate layer of 95% EtOH extract of the pericarps of A. yunnanensis, and identified as trans-linalool-3,6-oxide-7-O-β-D-(6'-O-acetyl)-glucoside (1), phenethyl-8-O-β-D-(6'-O-acetyl)-glucoside (2), mangiferin (3), iriflophenone-3,5-C-β-D-diglucoside (4), kaempferol-3-O-β-D-glucoside (5), luteolin-7-O-β-D-glucoside (6), isorhamnetin-3-O-β-D-glucoside (7), kaempferol-3-O-β-D-(6''-p-coumaroyl)-β-D-glucoside (8), geraniol-1-O-β-D-glucoside (9), 3-[2-formyl-5-(hydroxymethyl)-1H-pyrrol-1-yl] pentanedioic acid (10), cannabisin D (11), icariside D₂ (12), and coniferin (13). Conclusion Compound 1 is a new compound and compound 2 is a new natural product. Compounds 7, 9-13 were obtained from the Aquilaria genus for the first time. All compounds were firstly isolated from A. yunnanensis.

国家重点研发计划“中医药现代化研究”重点专项资助项目（2018YFC1706402）；国家中药标准化项目（ZYBZH-Y-GD-13-ZYY-2017-076）；创新天然药物与中药注射剂国家重点实验室开放课题（QFSKL2018001）