目的 对无柄灵芝Ganoderma resinaceum子实体的化学成分进行研究，以期发现新的化合物。方法 利用硅胶、MCI-GEL树脂及PR-HPLC等多种色谱技术进行分离纯化，并根据理化性质和波谱数据鉴定化合物的结构。结果 从云南瑞丽产无柄灵芝子实体中分离得到4个化合物，分别鉴定为无柄灵芝素F（1）、3β,7β,15β-三羟基-11,23-二酮基-羊毛脂-8,16-二烯-26-羧酸（2）、灵芝酸XL₂（3）和2,3-二氢-4（1H）-喹诺酮（4）。结论 其中化合物1为1个新的杂萜类成分，命名为无柄灵芝素F。

Objective For the purpose of finding new agents, the chemical study on Ganoderma resinaceum was carried out. Methods The chemical constituents from the dried fruiting bodies of G. resinaceum were isolated by column chromatographic methods of silica gel, MCI-Gel resin, and high performance liquid chromatography. The structures were elucidated by spectroscopic methods, including extensive 1D and 2D NMR techniques. Results Four compounds including one new meroterpenoid were isolated from this fungus. Their structures were identified as ganoresinains F (1), 3β,7β,15β-trihydroxy-11,23-dioxo-lanost-8,16-dien-26-oic acid (2), ganoderic acid XL₂ (3) and 2,3-dihydro-4(1H)-quinolone (4). Conclusion Compound 1 is a new compound and named as ganoresinains F (1).

国家自然科学基金资助项目（31600282）；国家自然科学基金资助项目（31560099）