目的 研究多枝雾水葛Pouzolzia zeylanica var.microphylla醋酸乙酯部位的化学成分。方法 采用95%乙醇回流提取，系统溶剂法对醇提物进行萃取，醋酸乙酯萃取部位通过正相、反相柱色谱，半制备高效液相色谱等方法进行分离，化合物通过波谱解析法确定结构。结果 从多枝雾水葛醋酸乙酯部位分离鉴定了10个化合物，分别为（2R，3S，4R，5S）-2，5-二-（4-羟基-3-甲氧基苯基）-3，4-二-（3，5-二羟基苯基）四氢呋喃（1）、pouzolignan K（2）、saropeptide（3）、去氢吐叶醇（4）、对羟基苯甲酸（5）、异香兰酸（6）、原儿茶酸（7）、丁香酸（8）、原儿茶醛（9）、原儿茶酸乙酯（10）。结论 化合物1为新化合物，命名为异雾水葛木脂素K，化合物3~10均为首次从该属植物中分离得到。

Objective To study the chemical constituents of Pouzolzia zeylanica var. microphylla. Methods 95% ethanol was used for reflux extraction. The solvent extraction method was used to extract the alcohol extracts. The ethyl acetate extracts were separated by normal phase and reversed phase column chromatography and semi-preparative high performance liquid chromatography. The compounds were determined by spectral analysis. Results Ten compounds were isolated and identified from the ethyl acetate part of P. zeylanicaas, which were (2R,3S,4R,5S)-2,5-bis (4-hydroxy-3-methoxyphenyl)-3,4-bis (3,5-dihydroxybenzene) terahydrofyran (1), pouzolignan K (2), saropeptide (3), dehydrocuciferol (4), p-hydroxybenzoic acid (5), isovanetic acid (6), protocatechuic acid (7), syringic acid (8), protocatechuic aldehyde (9), and ethyl protocatechuate (10), respectively. Conclusion Compound 1 is a new compound named isopouzolignan K, and compounds 3-10 are isolated from this genus for the first time.

R284.1

广东省科学技术厅项目（2016A020215158）；广东省科学技术厅项目（2014A020221095）；广东省科学技术厅项目（2015A030302088）