目的 研究中药复方连花清瘟胶囊的化学成分。方法 采用凝胶柱色谱、中低压色谱和高压制备液相色谱对连花清瘟胶囊总浸膏经大孔树脂吸附后的50%乙醇洗脱部分进行化合物的分离、纯化，并利用光谱数据进行结构鉴定。结果 从复方总浸膏中分离得到8个化合物，分别鉴定为10-O-（p-hydroxycinnamoyl）-adoxosidic acid（1）、芦荟大黄素-8-O-β-D-吡喃葡萄糖苷（2）、槲皮苷（3）、matairesinol-4'-O-β-D-glucoside（4）、芹糖甘草苷（5）、epi-vogeloside（6）、vogeloside（7）、咖啡酸乙酯（8）。结论 化合物1 为新化合物，命名为连花萜苷A，化合物5～8 首次从连花清瘟胶囊中分离得到，研究结果为连花清瘟胶囊质量控制的研究提供了物质基础。

Objective To study the chemical constituents of Lianhua Qingwen Capsules. Methods The compounds were isolated and purified by gel column chromatography, MPLC, and preparative HPLC from 50% ethanol fraction of macroporous resin column chromatography of Lianhua Qingwen crude extracts. Their structures were elucidated by the spectral analyses. Results Eight compounds were isolated and identified as 10-O-(p-hydroxycinnamoyl)-adoxosidic acid (1), aloe-emodin-8-O-β-D-glucopyranoside (2), quercitrin (3), matairesinol-4'-O-β-D-glucoside (4), liquiritin apioside (5), epi-vogeloside (6), vogeloside (7), and caffeic acid ethyl ester (8). Conclusion Compound 1 is a new compound named lianhua iridoid A. Compounds 5-8 are isolated from Lianhua Qingwen Capsules for the first time. This study provides substance foundation for chemical research of Lianhua Qingwen Capsules.

国家自然科学基金青年基金项目（81503231）；国家科技重大专项（2017ZX09307002）；北京市科技计划（Z171100004517014）