目的 优化地榆总皂苷的酸水解工艺，提高水解产物地榆皂苷元的产量。方法 采用正交试验设计，考察盐酸浓度、料液比、水解温度、水解时间对地榆总皂苷水解过程的影响。结果 影响水解的主次因素依次是盐酸浓度 > 水解时间 > 料液比 > 水解温度，优选的最佳工艺为料液比1∶200，盐酸浓度为4 mol/L，水解时间0.5 h，水解温度92 ℃。结论 采用优化后的水解条件能够得到产量较高的地榆皂苷元，适合工业化生产。

Objective To optimize the acid hydrolysis process of burnet (Sanguisorbae Radix, the roots of Sanguisorba officinalis) total saponins and to improve the yield of the hydrolyzate burnet sapogenin. Methods Using orthogonal test design, the concentration of hydrochloric acid, solid-liquid ratio, hydrolysis temperature, and hydrolytic time for the hydrolysis process of burnet total saponins were investigated. Results The primary and secondary factors that influenced the hydrolysis were followed by order of the concentration of hydrochloric acid > hydrolytic time > solid-liquid ratio > hydrolytic temperature, preferably optimum for the solid-liquid ratio of 1∶200, hydrochloric acid concentration of 4 mol/L, hydrolytic time of 0.5 h, and hydrolytic temperature of 92 ℃. Conclusion High yield of burnet sapogenin can be obtained by using the optimized hydrolytic conditions, which are suitable for industrial production.

国家自然科学基金项目（81373976）；国家新药创制重大专项（2013ZX09103002-013）