目的 研究芫花Daphne genkwa花蕾的化学成分。方法 利用正相硅胶柱色谱、薄层色谱等方法进行了化学成分的分离和纯化，根据理化性质和波谱数据进行了结构鉴定。结果 从芫花乙醇提取物中分离得到了3个木脂素类成分，分别鉴定为落叶松树脂醇-9-O-三十五烷酸酯（1）、松脂醇（2）、4-羟基芝麻素（3）。结论 化合物1为新的四氢呋喃型木脂素类成分，化合物3为首次从该植物中分离得到。

Objective To study the secondary metabolites of Genkwa Flos (the buds of Daphne genkwa). Methods The compounds were separated and purified by silica gel chromatography and thin layer chromatography, and their structures were determined by analyses of the physicochemical properties and spectral data. Results Three lignans were obtained and identified as lariciresinol- 9-O-pentatriacontanoate (1), pinoresinol (2), 4-hydroxysesamin (3) from the ethanol extract of D. genkwa. Conclusion Compound 1 is a new tetrahydrofuranoid lignan, and known compound 3 is obtained for the first time from this plant.

国家自然科学基金青年科学基金项目（81303202）；潍坊学院博士科研基金项目（2014BS09）