AP2/ERF转录因子也称为AP2/EREBP转录因子,广泛存在于植物中,其家族成员均含有由60个左右氨基酸组成的保守DNA结合域,即AP2/EREBP结合域。以往植物AP2/ERF转录因子研究主要集中于发育和生理调控领域,近年来AP2/ERF转录因子调控植物次生代谢产物合成方面引起关注。综述了AP2/ERF转录因子调控药用植物活性成分生物合成方面的研究进展,为利用代谢调控手段提高药用植物活性成分合成提供理论基础和应用借鉴。

AP2/ERF transcription factors are widely present in plants. Each member of AP2/ERF family contains a much conserved DNA binding domain, AP2/EREBP binding domain, which is composed by about 60 amino acids. The studies about plant AP2/ERF transcription factors mainly focused on the developmental and physiological regulation function. In recent years, the function of regulating secondary metabolites is being concerned. Here the research progress on AP2/ERF regulating the biosynthesis of active ingredient of medicinal plants was reviewed, which could be used for reference in further studies on improving the accumulation of active ingredients in medicinal plants by applying metabolic engineering.

中医药行业科研专项(201407005);成都中医药大学中药学国家级重点学科、中药资源系统研究与开发利用省部共建国家重点实验室培育基地开放研究基金资助项目(2014KFJJ05)