利用发明专利信息,对山药Dioscoreae Rhizoma的开发现状进行了分析。首先利用Espacenet及世界传统药物专利数据库收集专利信息。之后借助Python、R语言、SQLite等工具,对收集的专利信息进行筛选、整理、统计、分析、可视化等操作。得到了专利数据中反映山药的开发形势、趋势、国际格局及功能偏好、配伍偏好等方面的信息。从发明专利的视角可以看出,山药的开发目前处于发展初期;中国大陆对其开发投入很多,其他地域的投入较少;中国大陆的国际专利申请量最多;美国吸引的外地专利申请最多;专利申请涉及最多的是山药对消化系统疾病、代谢疾病和全身保护或抗毒剂等方面的治疗作用,具体的功能有助消化、治疗高血糖症、提高免疫力;其主要配伍思路有甘温益气、补脾益气等。

In order to provide a reference for the future development, the development status of Dioscoreae Rhizoma (also called Chinese yam) has been analyzed in the view of invention patent. We made the use of Espacenet and World Traditional Medicine Patent Database to collect patent information at first. Then we performed a series of process on the collected dataset, including screening, sorting, statistics, analysis, and visualization, with the help of Python, R, SQLite, and other tools. We got the development status information of Chinese yam that reflected in patent data, involving situation, trends, international structure, function preferences, and compatibility preferences. In the perspective of patents, Chinese yam is currently in the early stages of development-term, the development space is huge for future. Chinese mainland has invested a lot in the research of Chinese yam, comparing with other regions in the world. Chinese mainland owns the major part of international patent applications. The U.S. is the most attractive region for the applicants. Chinese yam is usually used in the treatment of digestive diseases, metabolic diseases, and systemic protection or anti-depress, detailed use includes helping digestion, treatment of hyperglycemia, and enhancing immunity. The ideal in common compatibility herbs is Gan-Wen-Yi-Qi, Bu-Pi-Yi-Qi, and others.

北京市科学技术委员会“首都市民健康项目培育”项目(Z131100006813045):生物药物专利信息服务系统研发