甾体化合物是一类重要的天然产物,在人类发展史上不仅为人类的健康做出了特殊的贡献,而且其立体结构的特殊性方面也在有机化学发展史,特别是有机化学理论上占有极其重要的地位,完善了立体化学理论。通过对甾体化合物的发现、生物活性、重要化合物的立体结构以及有机立体化学理论的发展、合成研究等发展历史进行简要介绍,为相关科研人员在教学和科研工作中提供一些启发和思路。

Steroids are the most important class of natural products. In the history of the development of human beings, not only steroidal compounds have made the special contribution for human health, but also its special stereochemical structure plays an important role in the development of organic chemistry, especially organic chemistry theory, which could improve the stereochemical theory. In this paper, the discovery, biological activity, the stereochemical structure of important compounds, stereochemistry, and the synthesis of steroids are briefly introduced for the purpose to broaden their horizon and provide some ideas for young teachers in the teaching and scientific research.

河北省中医药管理局科研计划项目(2014071);第54批中国博士后科学基金面上项目(2013M540214);第46批留学回国人员科研启动基金资助项目(王磊);河北省重点课题(ZD2016093);河北省高等教育学会高等教育科学研究课题资助项目(GJXH2013-141);河北医科大学教育科学研究重点课题资助项目(2012yb-19,2014yb-21)