目的 采用纳米喷雾干燥技术制备载药量高、收率高、吸湿性好的生地黄低聚糖微粉。方法 采用B-90纳米喷雾干燥仪制备生地黄低聚糖微粉,采用单因素试验考察后,通过正交试验设计,以平均粒径、收率和吸湿率为评价指标,考察进风口温度、喷雾干燥效率和药液质量分数对制备工艺的影响并优选最佳制备工艺。结果 正交试验结果得到最佳制备工艺条件:进风口温度为110℃、喷雾干燥效率为50%、药液质量分数为1.0%,最终得到了载药量为30%、收率为89%、吸湿性良好的生地黄低聚糖微粉,微粉形态稳定。结论 采用纳米喷雾干燥技术制备生地黄低聚糖的工艺稳定可行,得到的微粉质量良好,优于传统的喷雾干燥。

Objective To prepare Rehmanniae Radix oligosaccharide micro-powders with high load capacity, high yield, and good moisture absorption, using nano spray drying technology. Methods Based on the single factor experiments, the B-90 spray dryer was used to prepare Rehmanniae Radix oligosaccharide micro-powders with average particle size, yield, and moisture absorption rate as evaluation indices, and orthogonal test was used to investigate the influence of inlet temperature, spray drying efficiency, and solution concentration on the preparation process and to optimize the preparation process. Results The best spray drying condition was A₂B₂C₃, namely the inlet temperature was 110℃, the spray drying efficiency was 50%, and the drug concentration was 1%. Finally the drug loading was 30% and the yield was 89% with good moisture absorption. The Rehmanniae Radix oligosaccharide micro-powders had good morphology stability. Conclusion The nano spray drying technology is stable and the micro-powders have good quality, which is better than the traditional spray drying technology.

上海市科技攻关基金项目(05dz19702-3);2013年国家临床重点专科(中医专业)临床药学建设项目(财社[2013]239号);上海市科技专项计划项目(12401901401);上海市卫生局基金(2006Y001A)