目的 研究中华苦荬菜 Ixeris chinensis全草的化学成分。方法 采用硅胶柱色谱和高效液相色谱等方法分离纯化,依据理化性质及波谱数据鉴定化合物结构。结果 从中华苦荬菜全草中分离得到9个三萜类化合物,分别鉴定为20α-过氧羟基-3β-乌苏醇-21-烯(1)、3β,21α-二羟基羽扇豆-18-烯(2)、3β,25-二羟基-甘遂烷-7,23-二烯(3)、21α-羟基蒲公英甾醇-20(30)-烯(4)、羽扇豆醇(5)、3β-乌苏醇(6)、3β-齐墩果醇-18-烯(7)、3β-齐墩果醇(8)、3β-乌苏醇-20-烯(9)。结论 化合物1为新化合物,命名为苦荬菜三萜醇;化合物7为首次从该植物中分离得到。

Objective To study the chemical constituents of Ixeris chinensis. Methods The chemical constituents were isolated and purified by chromatography of silica gel column and HPLC, and their structures were elucidated by spectral analysis. Results Nine triterpenoids were isolated and identified as 20α-peroxide-3β-uvaol-21-en (1), 3β,21α-dihydroxylupen-18-en (2), 3β,25-dihydroxy-tirucalla-7,23-diene (3), 21α-hydroxy-taraxasterol-20(30)-en (4), lupeol (5), 3β-uvaol (6), 3β-oleanol-18-en (7), 3β-oleanol (8), and 3β-uvaol-20-en (9). Conclusion Compound 1 is a new compound, named ixeritriterpenol, and compound 7 is isolated from I. chinensis for the first time.

黑龙江省自然科学基金项目(B201205)