慢性肾病与炎症密切相关。中药或其提取物可干预核因子-κB(NF-κB)、丝裂原活化蛋白激酶(MAPK)及Toll样受体4(TLR4)等信号转导通路,并通过调节细胞因子、黏附分子、转录因子、受体分子及酶分子等多层次、多靶点拮抗慢性肾病肾组织炎性损伤。由于炎性损伤因素的交互性、网络性及放大性,使中药的干预作用有多点性、多效性和重叠性等特点。探索中药对慢性肾病肾组织炎性损伤的作用靶点及其分子机制对于慢性肾病的临床防治及新药研发具有重要意义。

Chronic kidney disease is closely related to inflammation. Chinese materia medica (CMM) or their extracts can intervene in some signal transduction paths such as nuclear factor-kappa B (NF-κB) path, mitogen activated protein kinase (MAPK) path, Toll-like receptor 4 (TLR4) path, and regulate cytokines, adhesion molecules, transcription factors, acceptor molecules, and enzyme molecules to resist inflammatory injury of renal tissue from multiple target points. Because of the interaction, network, and magnification of inflammatory injury factors, the action of CMM shows the characteristics, such as multi-point, pleiotropy, overlap, and so on. The target points of CMM on inflammatory injury are explored and their molecular mechanism plays an important role in the prevention and control of chronic kidney disease and study on new drug.

国家自然科学基金资助项目(81473652,81273684)