目的 研究半枝莲Scutellaria barbata全草的化学成分。方法 采用硅胶、MCI、反相ODS和Sephadex LH-20柱色谱进行分离和纯化,通过HR-ESI-MS、NMR、2D-NMR等波谱数据确定化合物的结构。结果 从半枝莲全草提取物中分离得到1个新克罗烷二萜,鉴定为(13R)-7β-羟基-8,13-螺-6α,11β-二乙酰氧基-3-烯-15,16-新克罗烷内酯。结论 化合物1为新的新克罗烷二萜化合物,命名为半枝莲二萜J。

Objective To study the chemical constituents from the whole plant of Scutellaria barbata. Methods The constituents were isolated and purified by using various column chromatographic techniques including silica gel column chromatography, MCI, ODS, and Sephadex LH-20, the structures were identified by spectroscopic analyses including HR-ESI-MS, NMR, and 2D-NMR. Results A new neoclerodane diterpenoid named scutelinquanine E was isolated from the whole plant of S. barbata, and its structrue was identified as (13R)-7β-hydroxy-8,13-epoxy-6α,11β-diacetoxy-ent-clerodan-3-en-15, 16-olide. Conclusion Compound 1 is a new neoclerodane diterpenoid named as scutellone J.

国家国际科技合作项目(2011DFA30870);中国中医科学院基本科研业务费自主选题项目(ZZ06080-02)