目的 研究白僵蚕Bombyx Batryticatus的化学成分。方法 利用正相硅胶柱色谱、Sephadex LH20、反相硅胶柱色谱及反相制备液相色谱等手段进行分离纯化, 并通过¹H-、¹³C-NMR等波谱技术进行结构鉴定。结果 从白僵蚕醋酸乙酯层中分离得到11个化合物, 分别鉴定为环(D-脯-D-缬)二肽(1)、环(S-脯-R-亮)二肽(2)、环(D-脯-D-异亮)二肽(3)、环(D-脯-D-苯丙)二肽(4)、金色酰胺醇酯(5)、(+)-松脂醇(6)、异黑麦草内酯(7)、butyl-2-pyrrolidone-5-carboxylate(8)、(-)-杜仲树脂酚(9)、(-)-落叶松树脂醇(10)、4-羟基苯乙酸甲酯(11)。结论 所有化合物均为首次从僵蚕中分离得到。

Objective To study the chemical constituents of Bombyx batryticatus. Methods The chemical constituents of B. batryticatus were isolated by different column chromatographic techniques, including silica gel and Sephadex LH-20 columns. The structures of these compounds were identified by a comprehensive analysis of the spectroscopic data. Results Eleven compounds were isolated from the EtOAc extract of B. batryticatus. The compounds were identified as cyclo (D)-Pro-(D)-Val (1), cyclo (S)-Pro-(R)-Leu (2), cyclo (D)-Pro-(D)-Ile (3), cyclo (D)-Pro-(D)-Phe (4), aurantiamid (5), (+)-pinoresinol (6), isololiolide (7), butyl-2-pyrrolidone-5-carboxylate (8), (-)-medioresinol (9), (-)-lariciresinol (10), and methylphydroxybenzeneacetate (11). Conclusion All the compounds are isolated from B. batryticatus for the first time.

江西省卫生厅项目(2014A005)