目的 观察血栓通注射液对伴有氯吡格雷抵抗(CR)脑梗死患者的血小板聚集的影响。方法 选取2012年3月—2014年8月在天津市天津医院神经科住院的急性脑梗死患者390例,从中挑选存在CR的患者104例,按1:1比例随机分为两组,即对照组和治疗组各52例,对照组患者在常规西医治疗的基础上加用氯吡格雷75 mg/d(口服),治疗组患者在对照组治疗的基础上给予血栓通注射液(5 mL溶于250 mL生理盐水中静脉滴注)。治疗组和对照组均治疗14 d,对比观察两组最大血小板聚集率的变化。结果 治疗后两组患者血小板聚集率均显著降低(P < 0.05);且治疗组血小板聚集率低于对照组(P < 0.05)。结论 血栓通注射液可降低伴有CR的脑梗死患者的血小板聚集水平,是CR治疗的有益补充。

Objective To observe the effect of Xueshuantong Injection on platelet aggregation in acute cerebral infarction patients with Clopidogrel resistance (CR). Methods This study selected acute cerebral infarction patients with CR from March 2012 to August 2014 in Tianjin Hospital. Patients (104 cases) were randomly divided into two groups (n = 52). The patients in the control group were treated with Western Medicine and Clopidogrel 75 mg/d, and the patients in treatment group were treated with Western Medicine and Clopidogrel 75 mg/d and given Xueshuantong Injection (5 mL dissolved in 0.9% saline 250 mL, iv drip). The two groups were treated for 14 d. Results The platelet aggregation in the two groups was reduced significantly after treatment (P < 0.05), and after treatment the platelet aggregation in the treatment group was lower than that in the control group (P < 0.05). Conclusion Xueshuantong Injection can reduce platelet aggregation in acute cerebral infarction patients with CR, and is a beneficial supplement therapy for CR.