β-淀粉样蛋白(β-amyloid, Aβ)的异常沉积与阿尔茨海默病(Alzheimer's disease, AD)的发生、发展密切相关。以Aβ为靶点, 寻找治疗AD的潜在药物是目前研究的热点。中药具有毒副作用小、多靶点、多途径、多环节的作用特点。总结近10年来国内外文献, 就中药成分通过减少Aβ产生、促进Aβ清除、拮抗Aβ毒性等几个方面阐述其对AD中Aβ靶点的影响。以期为中药成分防治AD的进一步研究提供参考。

Abnormal deposit of β-amyloid (Aβ) is closely related with the genesis and development of Alzheimer's disease (AD). Based on Aβ for target, looking for potential therapeutic agents in the treatment of AD is a hotspot of current research. Chinese materia medica (CMM) has small toxic side effect, with multi-target, multi-channel, and multi-link effect of functions and characteristics. According to vast information from literatures in the last decade, the composition of CMM can reduce Aβ production, promote Aβ clearance, and antagonize its toxicity, thus easing the development of AD. This article summarizes and reviews the research progress on Aβ targeting CMM, in hopes of providing a reference for further study in the future prevention of AD.

国家自然科学基金资助项目(81274118);科技部"重大新药创制"科技重大专项资助项目(2012ZX09103-201)