目的 观察牛蒡根水提物对高血压大鼠血管重塑的影响及其机制。方法 50只雌性Wistar大鼠用N-硝基-L-精氨酸(L-NNA)建立高血压大鼠模型, 随机分为模型组, 阳性对照组(卡托普利15 mg/kg), 牛蒡根水提物低、中、高剂量(0.5、1.0、2.0 g/kg)组, 连续ig给药6周, 检测大鼠收缩压(SBP), 血清血管紧张素II(Ang-II)、内皮素-1(ET-1)、肿瘤坏死因子-α(TNF-α)水平, 左心室质量指数(LVWI)及胸主动脉中膜厚度。结果 与对照组比较, 模型组大鼠SBP, 血清Ang-II、ET-1、TNF-α水平, LVWI及胸主动脉中膜厚度显著升高(P < 0.05);与模型组比较, 各给药组大鼠SBP、血清Ang-II、ET-1、TNF-α水平, LVWI及胸主动脉中膜厚度均显著降低(P < 0.05)。结论 牛蒡根水提物可改善高血压大鼠血管重塑。

Objective To observe the effect of aqueous extract from roots of Arctium lappa (AERAL) on vascular remolding in hypertensive rats. Methods The hypertensive rat model was induced by N-nitro-L-arginine from 50 female Wistar rats, and randomly divided into model control group, positive control group (15 mg/kg), low-, mid-, and high-dose AERAL (0.5, 1.0, and 2.0 g/kg), groups. After six weeks of continuous gavage administration, rat tail artery systolic pressure, angiotensin II (Ang-II), endothelin-1 (ET-1), tumor necrosis factor-α (TNF-α), left ventricular mass index (LVWI), and thickness of thoracic aortic tunica media (TTATM) were detected. Results Compared with the normal control group, Ang-II, ET-1, TNF-α, LVWI, and TTATM were increased and rat tail artery systolic pressure was elevated in the model control group, with significant differences between the two groups (P < 0.05); Compared with the model control group, rat tail artery systolic pressure in each treatment groups declined, serum Ang-II, ET-1, TNF-α, LVWI, and TTATM were all lowered, showing significant differences among them (P < 0.05). Conclusion AERAL can significantly improve vascular remolding in rats with hypertension.

广西中医药民族医药传承创新专项立项课题(GZLC14-38);2014年国家级大学生创新创业训练计划项目(G201410601005);广西壮族自治区大学生创新创业训练项目(201410601019)