溃疡性结肠炎是一种慢性、非特异性肠病, 其发病机制尚不明确。目前的治疗以氨基水杨酸、类固醇激素与免疫抑制剂3类药物为主, 但是无法有效的防治, 不可长期使用。近年来, 大量研究以中药复方、单味药或者活性成分为研究对象, 以期开发出治疗、预防溃疡性结肠炎的新型药物。就NF-κB信号通路在溃疡性结肠炎中的作用及以NF-κB通路中相关蛋白和酶为靶点的中药抗溃疡性结肠炎的研究进展进行综述。

Ulcerative colitis (UC) is a chronic and relapsing condition of the intestinal inflammation of unknown etiology and remains one of the most intractable gastrointestinal diseases, impairing quality of life and carrying a high risk of colorectal cancer in patients with UC. Currently, aminosalicylic acid, steroid hormone, and immunosuppressor are the main drugs for treating UC. However, all of them can not cure UC once and for all. In recent years, many scholars attempted to find new drugs in the extracts and active compounds from herbs for the prevention and treatment of UC. The paper summarized the status of nuclear factor kappa B (NF-κB) signal pathway of UC, and those anti-inflammation Chinese materia medica regarded proteins and enzymes of NF-κB pathway as targets.

国家"973"项目课题(2013CB531801);黑龙江省教育厅科学技术研究项目(12541818)