目的 研究腺梗豨莶Siegesbeckia pubescens地上部分的化学成分.方法 利用正相硅胶柱色谱、薄层色谱等方法进行了化学成分的分离和纯化,根据理化性质和波谱数据进行了结构鉴定.结果 从腺梗豨莶地上部分乙醇提取物中分离得到了3个氧化脂类成分,分别鉴定为3-豆蔻酰氧基-2-异丁酰氧基-4-甲基戊酸(1)、3-豆蔻酰氧基-2-羟基-4-甲基戊酸(2)和γ-十二烷基-α-羟基-γ-内酯(3).结论 化合物1和2为首次报道的氧化脂类新化合物,分别命名为豨莶脂A和豨莶脂B,化合物3为首次从该植物中分离得到.

Objective To study the chemical constituents from the aerial parts of Siegesbeckia pubescens. Methods The compounds were separated and purified by silica gel column chromatography and TLC, and their structures were determined by analyses on the physicochemical properties and spectral data. Results Three oxylipins were obtained and identified as 3-(myristoyloxy)-2- (isobutyloxy)-4-methylpentanoic acid (1), 3-(myristoyloxy)-2-hydroxy-4-methylpentanoic acid (2), and γ-dodecyl-α-hydroxy-γ- lactone (3) from the ethanol extract of S. pubescens. Conclusion The two new oxylipins 1 and 2, named siegesbeclipin A and siegesbeclipin B, and known compound 3 is obtained from this plant for the first time.

国家自然科学基金青年科学基金项目(81303202)