目的 研究国产沉香Aquilariae Lignum Resinatum的小极性化学成分.方法 采用硅胶、Sephadex LH-20凝胶、半制备高效液相色谱等方法进行分离纯化,并通过NMR、MS等波谱学方法鉴定化合物的结构.结果 从国产沉香的石油醚提取物的中分离得到9个化合物,分别鉴定为18-降去氢松香酸-4α,7α-二醇(1)、18-降去氢松香酸-4α,7β-二醇(2)、7α-羟基去氢松香酸(3)、2α-羟基去氢松香酸(4)、2β-羟基去氢松香酸(5)、7α,15-二羟基去氢松香酸甲酯(6)、7-羰基-13β-羟基松香-8(14)-烯-18-羧酸(7)、2β-羟基海松酸(8)、3β-羟基海松醇(9).结论 化合物1～9均为首次从沉香属植物中分离得到的二萜类化合物,其中化合物1和2为降二萜类化合物,化合物3～9为二萜类化合物.

Objective To study the chemical constituents of small polar in Aquilariae Lignum Resinatum. Methods The column chromatography on silica gel, Sephadex LH-20, and semi-preparative HPLC was used to separate and purify the compounds, their structures were elucidated by NMR and MS spectroscopic data analyses. Results Nine compounds were isolated from the petroleum ether of Aquilariae Lignum Resinatum and identified as 18-nor-abieta-8,11,13-triene-4α,7α-diol (1), 18-norabieta-8,11,13-triene-4α, 7β-diol (2), 7α-hydroxydehydroabietic acid (3), 2α-hydroxydehydroabietic acid (4), 2β-hydroxydehydroabietic acid (5), 7α,15-dihydroxy-methyl-dehydroabietate (6), 7-oxo-13β-hydroxyabiet-8(14)-en-18-oic acid (7), 2β-hydroxypimaric acid (8), and 3β-hydroxypimarol (9). Conclusion All the compounds are isolated from the plants of Aquilaria Lam. for the first time, among them, compounds 1 and 2 are norditerpenoids and compounds 3-9 are diterpenoids.

国家自然科学基金资助项目(81273405)