方剂配伍作为中药复方的组成原则,是解析中药复方规律性的关键.立足中药复方与生物机体相互作用过程,从中药复方化学、药物代谢动力学和药物效应动力学3方面探讨方剂配伍的现代科学内涵.中药复方化学是解析方剂配伍现代科学内涵的基础,配伍引起的化学变化,包括量变和质变,属方剂配伍的化学内涵;方剂配伍能够改变药物的代谢动力学行为,通过调节药物代谢过程关键环节来影响复方疗效和毒性反应;方剂组成影响配伍疗效,为了研究方剂配伍治疗机制,提出了"疾病病理生理指导的药物靶点组合"方法来研究中药复方化学多成分作用于机体多靶点现象,为理解方剂配伍增效/减毒作用机制和推动中药复方现代科学研究提供参考.

As the fundamental rule to construct multi-herb prescriptions of Chinese materia medica (CMM), formula compatibility is the key to study the principles of CMM prescriptions. Modern scientific connotation on the formula compatibility could be investigated on the aspects of chemistry, pharmacokinetics, and pharmacodynamics, according to the interactions between CMM prescriptions and the organism. The chemistry of CMM prescriptions is a prerequisite to investigate formula compatibility, and chemical alterations, including quantitative and qualitative changes,induced by formula compatibility are especially emphasized. Formula compatibility can modify the pharmacokinetic behavior of drugs by regulating key steps of pharmacokinetic process to influence the effect and toxicity of CMM prescriptions. Ingredients of a formula affect its therapeutic actions;to elucidate the therapeutic mechanisms of formula compatibility, a new method named "combination of drug targets guided by the pathophysiology of diseases" is proposed to investigate the phenomenon that multi-components of a formula act on multi-target in the organism. It sheds light on understanding the mechanisms of improving effect/reducing toxicity of formula compatibility and provides the reference to enhance the modern scientific research of CMM prescriptions.

天津市应用基础及前沿技术研究计划项目(12JCYBJC32400);国家"重大新药创制"科技重大专项(2012ZX09101212);科技部国家国际合作专项(2013DFA31620)