目的 研究臭红菇Russula foetens子实体的化学成分.方法 通过硅胶、Sephadex LH-20柱色谱分离其子实体中的化合物,运用氢谱、碳谱、二维核磁共振(¹H-¹H COSY、HMQC、HMBC、NOESY)、高分辨质谱、红外等波谱学方法鉴定化合物结构.结果 共分离得到11个化合物,分别鉴定为6个倍半萜(1～6):8β, 13-二羟基-小皮伞烷-5β-甲氧基γ-乙缩醛(1)、13-羟基-小皮伞烷-7(8)-烯-5-甲氧基γ-乙缩醛(2)、8β, 13-二羟基-小皮伞烷-5-羰基γ-内酯(3)、8β, 13, 14-三羟基-小皮伞烷-5-羰基γ-内酯(4)、7, 8, 13-三羟基-小皮伞烷-5-羰基γ-内酯(5)、lactapiperanol A(6),3个甾醇(7～9):(22E, 24R)-麦角甾-7, 22-二烯-3, 5, 6-三醇(7)、麦角甾-5, 7, 22-三烯-3-醇(8)、3-羟基-5, 8-过氧麦角甾-6, 22-二烯(9),尿嘧啶核苷(10)、D-阿洛糖醇(11).结论 化合物1～4是从臭红菇中分离得到的新化合物,分别命名为红菇醛萜、红菇醛萜烯、红菇酮萜、红菇酮萜醇.化合物7、8、10、11为首次从臭红菇中分离得到.

Objective To study the chemical constituents of Russula foetens. Methods The chemical constituents were isolated by repeated silica gel and Sephadex LH-20 column chromatography, and their structures were elucidated by ¹H-NMR, ¹³C-NMR, 2D-NMR (¹H-¹H COSY, HMQC, HMBC, NOESY), HR-MS, CD, and IR. Results Eleven compounds were isolated from the fruiting bodies of R. foetens. Of which, six marasmane sesquiterpenes: 8β, 13-dihydroxy-marasm-5β-methoxy γ-acetal (1), 13-hydroxy-marasm-7(8)-en-5-methoxy γ-acetal (2), 8β, 13-dihydroxy-marasm-5-oic acid γ-lactone (3), 8β, 13, 14-trihydroxy- marasm-5-oic acid γ-lactone (4), 7, 8, 13-trihydroxy-marasm-5-oic acid γ-lactone (5), and lactapiperanol A (6); three steroids: (22E, 24R)-ergosta-7, 22-dien-3, 5, 6-triol (7), ergosta-5, 7, 22-trien-3-ol (8), 3-hydroxy-5, 8-epidioxy-ergosta-6, 22-dien (9); and uridine (10), D-allitol (11) were identified. Conclusion Compounds 1—4, named as russacetal, russacetalen, russunone, and russunoneol respectively, are new compounds isolated from R. foetens. Compounds 7, 8, 10, and 11 in this fungus are first reported.

江苏省自主创新基金 [CX(12)5028]