目的 探讨川芎嗪、阿魏酸对延胡索乙素大鼠体内的药动学规律的影响。方法 32只SD大鼠，分为延胡索乙素（20 mg/kg）组、延胡索乙素（20 mg/kg）+阿魏酸（50 mg/kg）组、延胡索乙素（20 mg/kg）+川芎嗪（30 mg/kg）组、延胡索乙素（20 mg/kg）+川芎嗪（30 mg/kg）+阿魏酸（50 mg/kg）组，各组单剂量ig给药，采用RP-HPLC法分别测定各组大鼠血浆中延胡索乙素的浓度，DAS2.0程序计算药动学参数。结果 延胡索乙素与阿魏酸或者川芎嗪联合给药时，AUC_0~t、和C_max与延胡索乙素单独给药相比显著增加，t_max、t_1/2和MRT_0~t比延胡索乙素单独给药时显著延长（P<0.05）；延胡索乙素同时与阿魏酸、川芎嗪二者联合给药时AUC_0~t、MRT_0~t、t_1/2和t_max与延胡索乙素单独给药相比显著增大（P<0.05），而C_max与延胡索乙素单独给药时相比无显著差异。结论 阿魏酸、川芎嗪可以显著增加延胡索乙素在大鼠体内的吸收，并显著延长延胡索乙素在大鼠体内的作用时间。

Objective To investigate the effects of tetramethylpyrazine (TMP) and ferulic acid (FA) on pharmacokinetics of tetrahydropalmatine (THP) in rats. Methods Thirty-two Sprague-Dawley rats were randomly divided into four groups such as THP 20 mg·kg^-1, THP 20 mg·kg^-1 + FA 50 mg·kg^-1, THP 20 mg·kg^-1 + TMP 30 mg·kg^-1, and THP 20 mg·kg^-1 + FA50 mg·kg^-1 + TMP 30 mg·kg^-1 groups. All the rats were ig administered and then blood samples were obtained from fossa orbitalis at several time points. All the plasma concentration was analyzed by RP-HPLC method and the data were treated by DAS 2.0 program. Results Compared with THP alone, THP combined with TMP or FA could increase the AUC_0~t, t_max, and C_max, and prolong the t_1/2 and MRT_0~t (P < 0.05). Compared with THP alone, THP combined with TMP and FA could increase the AUC_0~t, MRT_0~t, t_1/2, and t_max, but had no influence on the C_max. Conclusion FA and TMP can prolong the action time of THP in rats, and increase of THP absorption in rats in vivo.

重庆市自然科学基金资助项目（CSTC2012jjA10012）；重庆市重大科技攻关项目（CSTC2008AA5004）