8-异戊烯基黄酮类化合物是黄酮类化合物中的一种，异戊烯基的存在极大地增强了黄酮类化合物的亲脂性，可引起相关生物活性的显著提高。论述了黄酮类化合物A环8位异戊烯基化对母体结构化合物在抗氧化、抗骨吸收活性、抗微生物活性、抗肿瘤以及酪氨酸酶抑制作用等生物活性方面的影响。

The flavonoids with the prenylation on site 8 are a unique class of natural flavonoids. The existence of prenyl-moiety could dramatically increase the lipophilicity and the relevant bioactivities of flavonoids. This review discussed the influences of the prenylation at C-8 of ring A in flavonoids on the activities of antioxidant, anti-bone resorption, antimicrobial activity, anti-tumor activity, and tyrosinase inhibition of the backbone flavonoids.

国家自然科学基金资助项目（81202894）