目的 研究穆库尔没药Commiphora mukul树脂的化学成分。方法 采用硅胶和Sephadex LH-20凝胶柱色谱法进行分离纯化，运用波谱学方法鉴定化合物的结构。结果 从穆库尔没药树脂醋酸乙酯提取物中分离获得2个吉玛烷型倍半萜化合物，分别鉴定为1α，8α，12α-三羟基-2β-甲氧基-8，12-环氧吉玛烷-7（11），9-二烯-6-酮（1）和1α，8β，12α-三羟基-2β-甲氧基-8，12-环氧吉玛烷-7（11），9-二烯-6-酮（2）。结论 2个吉玛烷型倍半萜化合物1和2为未见文献报道的新化合物，分别命名为穆库尔素A（1）和穆库尔素B（2）。

Objective To investigate the chemical constituents from the resin of Commiphora mukul. Methods Silica gel and Sephadex LH-20 column chromatographies were used for the purification, and spectroscopic techniques were adopted for the structure elucidation. Results Two germacrane-type sesquiterpenoids have been isolated from the resin of C.mukul, which were identified to be 1α, 8α, 12α-trihydroxy-2β-methoxy-8, 12-epoxygermacra-7(11), 9-dien-6-one (1) and 1α, 8β, 12α-trihydroxy-2β-methoxy-8, 12-epoxygermacra-7(11), 9-dien-6-one (2). Conclusion These two sesquiterpenoids are new compounds named as mukulsin A (1) and mukulsin B (2), respectively.

国家自然科学基金资助项目（81001376）；中国博士后基金（201104602，20100471536）；山东省博士后创新基金（201002018）