[关键词]
[摘要]
目的 研究地骨皮Lycii Cortex（root bark of Lycium chinense）的化学成分。方法 采用硅胶、Sephadex LH-20、ODS等多种色谱学方法分离纯化，根据理化性质和波谱数据进行结构鉴定。结果 从地骨皮95%乙醇提取物的醋酸乙酯部位中分离得到12个化合物，分别鉴定为反式-N-对羟基香豆酰酪胺（1）、反式-N-阿魏酰酪胺（2）、二氢咖啡酰酪胺（3）、芹菜素（4）、阿魏酸（5）、对羟基香豆酸（6）、3-羟基-1-（4-羟基苯基）-丙基-1-酮（7）、3，4-二羟基苯丙酸（8）、3，4-二羟基苯丙酸甲酯（9）、对羟基苯甲酸（10）、4-甲氧基水杨酸（11）、烟酸（12）。结论 化合物8和9为新的天然产物，化合物1、6、11及12为从该植物中首次分离得到。
[Key word]
[Abstract]
Objective To study the chemical constituents from the root barks of Lycium chinense. Methods The chemical constituents of EtOAc fraction from 95% ethanol extract of L. chinense were isolated and purified by chromatography on silica gel, Sephadex LH-20, and ODS. Their chemical structures were identified on the basis of physicochemical properties and spectroscopic data. Results Twelve compounds were isolated and identified as N-trans-coumaroyltyramine (1), N-trans-feruloyltyramine (2), dihydro-N-caffeoyltyramine (3), apigenin (4), ferulic acid (5), p-hydroxycinnamic acid (6), 3-hydroxy-1-(4-hydroxyphenyl)-1- propanone (7), 3, 4-dihydroxybenzenepropionic acid (8), 3, 4-dihydroxybenzenepropionic acid methyl ester (9), p-hydroxy-benzoic acid (10), 4-methoxy salicylic acid (11), and nicotinic acid (12). Conclusion Compounds 8 and 9 are two new natural products, and compounds 1, 6, 11, and 12 are obtained from this plant for the first time.
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[基金项目]
科技部课题“重大新药创制”科技重大专项公共资源平台课题“面向新药发现的数字化中药化学成分库”（2011ZX09307-002-01）
