目的 比较五味子、醋五味子、酒五味子对肾阳虚小鼠的影响，为五味子“入补药熟用”的研究及临床合理应用提供科学依据。方法 采用小鼠ig给予腺嘌呤方法制备肾阳虚模型，以桂附地黄丸为阳性对照，以小鼠体征，血清皮质醇、睾酮、肌酐（Cr）水平，精囊腺、睾丸的脏器指数，及睾丸、肾脏组织病理观察等为评价指标，比较五味子、醋五味子、酒五味子水煎液的补肾阳作用。结果 五味子、醋五味子、酒五味子对肾阳虚小鼠均有一定的治疗作用，可改善小鼠的激素水平，增加脏器指数，其中酒五味子作用最好，各剂量组以中剂量组作用最好。结论 炮制与剂量均会对五味子补肾阳作用产生影响，临床应用于治疗肾阳虚时应首选酒五味子，并注意五味子的使用剂量。

Objective To provide the scientific basis for the research and clinical application of "the processed Schisandrae Fructus as a tonic" through comparing the effects of raw, vinegar steaming and wine steaming Schisandrae Fructus on tonifying kidney-yang of mice. Methods The kidney-yang deficiency mouse model was established by adenine. With Fugui Dihuang Pill as positive control drug, the effects of raw and differently processed Schisandrae Fructus on kidney-yang deficiency mice were compared regarding by the contents of serum cortisol, testosterone, creatinine, the viscera indexes of seminal vesicle, testicle, and the pathological sections of testis and kidney. Results The raw and differently processed Schisandrae Fructus had certain therapeutic effects on kidney-yang deficiency mice, such as meliorating the hormonal condition and raising the viscera index of kidney-yang deficiency mice. In terms of therapeutic effects, the wine steaming Schisandrae Fructus was the best among the different kinds of Schisandrae Fructus, and the mid-dose was better than others. Conclusion Both of the processing methods and dosages of Schisandrae Fructus will affect the therapeutic action on kidney-yang deficiency. The wine steaming Schisandrae Fructus is preferred in the treatment for kidney-yang deficiency, and the dosage should be paid attention to.

国家发改委2011年中医药行业科研专项项目：19种生熟异用中药饮片临床规范使用研究（20110700704）