目的 研究不同干燥方法对何首乌药材中二苯乙烯苷类和蒽醌类活性成分转化的影响，为何首乌药材产地干燥加工适宜方法的建立提供科学依据。方法 以新鲜野生何首乌块根为材料，分别采用阴干、晒干、烘干、冷冻干燥、微波干燥、远红外干燥6种干燥加工方法处理，采用HPLC法同时测定经各种干燥方法制备的样品及不同烘干时间样品中二苯乙烯苷、游离型蒽醌类和结合型蒽醌类化学成分的量。结果 经6种不同干燥方法处理的样品中，二苯乙烯苷的量由高至低依次为晒干＞远红外干燥＞冷冻干燥＞阴干＞烘干＞微波干燥；阴干法和烘干法更适宜于结合型蒽醌类成分转化为游离型蒽醌类成分；采用远红外干燥的样品，其结合型蒽醌的量最高。主成分分析综合评价显示，经远红外干燥法制备的何首乌药材其综合评价指数明显高于其他干燥方式。结论 远红外干燥法为何首乌药材适宜的产地干燥加工方法。

Objective To explore the effects of different drying methods on the transformation of bioactive constituents, such as stilbene glycosides and anthraquinones, in Polygoni Multiflori Radix (PMR), and to provide a scientific evidence for the suitable drying method for PMR. Methods Using crude PMR as materials, six drying methods including shade-drying, sun-drying, oven-drying, freeze-drying, microwave-drying, and far-infrared-drying were used to process the samples of PMR. HPLC was used to simultaneously determine the contents of stilbene glycosides, free and conjugated anthraquinones with different drying methods and drying time. Results The contents of stilbene glycosides in the samples processed with the above methods were as follows in descending order: sun-drying > far-infrared-drying > freeze-drying > shade-drying > oven-drying > microwave-drying; The shade-drying and sun-drying methods were more suitable for the conjugated anthraquinones transforming into the free ones and the contents of conjugated anthraquinones in the sample processed with far-infrared-drying method were the highest. The comprehensive evaluation index obtained with principal component analysis showed that the far-infrared-drying method is significantly higher than those with other drying methods for PMR. Conclusion Far-infrared-drying method is the suitable approach for the primary drying processing of PMR.

江苏高校优势学科建设工程资助项目（ysxk-2010）；江苏省高校优秀科技创新团队-中药资源化学研究（2011-2014）