目的 优选醋制紫硇砂最佳炮制工艺。方法 以小鼠耳肿胀抑制率、半数致死量（LD₅₀）和氯化钠质量分数作为指标，选择加水量、醋用量、粒度及析晶时间4个因素，用L₉(3⁴) 正交设计表，采用方差分析，对紫硇砂醋制工艺进行优选。结果 醋制紫硇砂最佳炮制工艺为选择过40目筛的紫硇砂，加5倍量水，加饮片总量50%的醋，控制析晶时间为60 min。结论 该工艺设计合理，稳定可靠，为醋制紫硇砂的质量控制奠定了基础。

Objective To optimize the processing technique for vinegar-processed Halite Violaceous. Methods The ear swelling, median lethal dose (LD₅₀), and content of sodium chloride were chosen as indicators, the optimal technique was investigated by the factors of water amount, vinegar amount, particle size, and crystallization time, and determined by L₉(3⁴) orthogonal test and varience analysis. Results The optimal processing conditions were as follows: using 40 mesh to screen Helite Violaceous, adding the amount of water in five times, and 50% of the total increase vinegar as total amount as pieces, and controlling the crystallization time to 60 min. Conclusion The processing technology is reasonable, stable, and feasible, which could lay a solid foundation for the quality control of vinegar-processed Halite Violaceous.

国家中医药管理局公益性行业专项（200807039）