目的 探讨彝药塔若散水提液对早期动脉粥样硬化金黄地鼠的影响。方法 金黄地鼠在高脂饲料喂饲的基础上，ip维生素D₃诱导早期动脉粥样硬化模型。造模9周后，将早期动脉粥样硬化大鼠分为模型组、辛伐他汀（4.2 mg/kg）阳性对照组、塔若散水提液高和低剂量（生药16.8、2.1 g/kg）组，每天ig给药1次，连续给药11周，另设对照组。给药结束后检测金黄地鼠血清总胆固醇（TC）、三酰甘油（TG）、低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白胆固醇（HDL-C）水平以及白细胞介素-1β（IL-1β）、肿瘤坏死因子-α（TNF-α）、基质金属蛋白酶-9（MMP-9）和基质金属蛋白酶组织抑制因子-1（TIMP-1）的量；HE染色法观察颈总动脉组织形态学的变化；计算肝脏指数。结果 与模型组比较，各给药组大鼠血清TC、TG、LDL-C水平以及IL-1β、TNF-α、MMP-9的量均不同程度地降低，TIMP-1的量升高，颈总动脉和肝脏的病理变化均得到不同程度的改善。结论 塔若散对早期动脉粥样硬化具有一定的治疗作用，其机制可能与调节血脂水平和血清中炎症因子以及协调MMP-9/TIMP-1的失衡有关。

Objective To observe the effect of water extract from Yi Medicine Taruosan (a prescription of podwer) on prophase atherosclerosis in golden hamster. Methods The golden hamsters were injected with VD₃, while fed with high cholesterol diet. After nine weeks, the models were established successfully. The golden hamsters were devided into model, Simvastatin (4.2 mg/kg), and high- and low-dose (16.8 and 2.1 g/kg) Taruosan water extract groups. The animals were ig administered once daily for 11 weeks, and the animals in the control group were not administered. After administration, the levels of total cholesterol (TC), triacylglycerol (TG), low density lipoprotein cholestorol (LDL-C), and high density lipoprotein cholesferol (HDL-C) and the contents of interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α), matrix metalloproteinase-9 (MMP-9), and tissue-inhibitor of metalloproteinase-1 (TIMP-1) were analyzed. Carotid histomorphological changes were observed by HE staining. Hepatic lesions were evaluated by liver index. Results Compared with the model group, the levels of TC, TG, LDL-C, IL-1β, TNF-α, and MMP-9 were reduced, the level of TIMP-1 increased, and the carotid artery and hepatic pathological changes were improved in the other groups. Conclusion Taruosan has a therapeutic effect on prophase atherosclerosis, which may be due to regulating the lipid metabolism, reducing the level of inflammatory factors, and conditioning the imbalance state of MMP-9/TIMP-1.

国家自然科学基金青年科学基金资助项目（81102663）