目的 研究蓍草Achillea alpina 地上部分的化学成分。方法 利用多种柱色谱手段进行分离与纯化，通过理化性质和波谱数据鉴定化合物的结构。结果 从蓍草乙醇提取物的氯仿萃取部分分离得到11个化合物，分别鉴定为表木栓醇（1）、菠菜甾醇（2）、β-谷甾醇（3）、5, 6-epoxy-24(R)-methylcholesta-7, 22-dien-3β-ol（4）、β-胡萝卜苷（5）、schensianol A（6）、negunfurol（7）、(3S, 5S, 8R)-3, 5-dihydroxymegastigma-6, 7-dien-9-one（8）、saropeptate（9）、(＋)-丁香脂素（10）、(±)-落叶松树脂醇（11）。结论 所有化合物均为首次从该植物中分离得到，其中化合物1、2、4、6～11为首次从该属植物中分离得到。

Objective To investigate the chemical constituents from the aerial parts of Achillea alpina. Methods The compounds were isolated and purified by various chromatographic techniques and their structures were characterized on the basis of physicochemical properties and their spectral analyses. Results Eleven compounds were isolated. Their structures were identified as epifriedelanol (1), spinasterol (2), β-sitosterol (3), 5, 6-epoxy-24(R)-methylcholesta-7, 22-dien-3β-ol (4), β-daucosterol (5), schensianol A (6), negunfurol (7), (3S, 5S, 8R)-3, 5-dihydroxymegastigma-6, 7-dien-9-one (8), saropeptate (9), (+)-syringaresinol (10), and (±)-lariciresinol (11). Conclusion All the compounds are isolated from the aerial parts of A. alpina for the first time, and compounds 1, 2, 4, 6—11 are reported to obtain from the plants in Achillea L. for the first time.

国家“十一五”规划重大科技专项——先导化合物的发现与优化技术平台（2009ZX09301-011）；国家自然科学基金资助项目（81273401）；科技部“重大新药创制”重大专项公共资源平台“面向新药发现的数字化中药化学成分库”（2011ZX09307-002-01）