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[摘要]
目的 研究宽裂龙蒿Artemisia dracunculus var. turkestanica地上部分的化学成分。方法 采用硅胶、RP18、Sephadex LH-20等柱色谱进行分离与纯化,通过理化性质和波谱数据鉴定化合物的结构。结果 从宽裂龙蒿地上部位95%乙醇提取物的醋酸乙酯部位分离得到19种化合物,分别鉴定为1-棕榈酸单甘油酯(1)、α-亚麻酸甲酯(2)、1-油酸单甘油酯(3)、乙酰熊果酸(4)、3β, 22β, 24-三羟基-齐墩果-12-烯(5)、油酸(6)、棕榈酸(7)、1-亚油酸单甘油酯(8)、香草酸(9)、橙皮素(10)、柚皮素(11)、槲皮素(12)、芦丁(13)、滨蒿内酯(14)、东莨菪亭(15)、7-羟基香豆素(16)、瑞香素(17)、咖啡酸(18)、绿原酸(19)。结论 所有化合物均首次从该植物中分离得到,其中化合物1~5和8为首次从该属植物中分离得到。
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[Abstract]
Objective To study the chemical constituents from the aerial parts of Artemisia dracunculus var. turkestanica. Methods The compounds were isolated and purified by silica gel, RP18, and Sephadex LH-20 column chromatography, and their structures were elucidated on the basis of spectral data and physicochemical properties. Results Nineteen compounds were obtained from ethyl acetate fraction of the 95% ethanol extract from the aerial parts of A. dracunculus var. turkestanica and identified as 1-monopalmitin (1), α-methyl linolenate (2), 1-monoolein (3), 3-O-acetyl ursolic acid (4), 3β, 22β, 24-trihydroxy-olean-12-en (5), oleic acid (6), palmitic acid (7), 1-monolinolein (8), vanillic acid (9), hesperetin (10), naringenin (11), quercetin (12), rutin (13), scoparone (14), scopoletin (15), 7-hydroxycoumarin (16), daphnetin (17), caffeic acid (18), and chlorogenic acid (19). Conclusion All the compounds are isolated from A. dracunculus var. turkestanica for the first time. Compounds 1—5 and 8 are firstly reported in the plants of Artemisia L.
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[基金项目]
国家自然科学基金资助项目(21162028);中国科学院“西部之光”人才培养计划