目的 研究毛酸浆Physalis pubescens干燥宿萼的化学成分。方法 利用硅胶柱色谱法、Sephadex LH-20凝胶柱色谱法、中压柱色谱及半制备高效液相色谱等方法分离纯化，通过核磁共振谱、质谱等光谱数据鉴定化合物结构。结果 分离得到9个化合物，分别鉴定为3, 6, 11-三甲基-3-羟基-1, 6(E), 10-十二碳三烯-8-O-β-D-葡萄糖苷（1）、3′, 5-二羟基-3, 7, 4′-三甲氧基黄酮（2）、山柰酚-3-O-β-D-槐糖苷（3）、山柰酚-3-O-α-L-鼠李糖-(1→6)-β-D-葡萄糖苷（4）、山柰酚-3-O-β-D-葡萄糖-7-O-α-L-鼠李糖苷（5）、3-羟基-4-甲氧基苯甲酸（6）、银杏内酯A（7）、银杏内酯B（8）、3, 7, 4′-三甲氧基杨梅黄酮（9）。结论 化合物1为新化合物，命名为毛酸浆苷A，化合物2～8为首次从该属植物中分离得到。

Objective To investigate the chemical constituents in the dried persistent calyx of Physalis pubescens. Methods The constituents were isolated by chromatography on silica gel, Sephadex LH-20, and medium pressure columns, and semi-preparative liquid chromatography, then their structures were elucidated by chemical properties and spectroscopic analyses. Results Nine compounds were isolated and their structures were identified to be 3, 6, 11-trimethyl-3-hydroxyl-1, 6(E), 10-dodecatriene-8-O-β- D-glucoside (1), 3′, 5-dihydroxy-3, 7, 4′-trimethoxyl flavone (2), kaempferol-3-O-β-D-sophoroside (3), kaempferol-3-O-α-L- rhamnosterin-(1→6)-β-D-glucoside (4), kaempferol-3-O-β-D-glucoside-7-O-α-L-rhamnosterin (5), 3-hydroxyl-4-methoxy benzoic acid (6), ginkgolide A (7), ginkgolide B (8), and 3, 7, 4′-trimethyl-myricetin (9). Conclusion Compound 1 is a new compound named physaliside A and compounds 2—8 are obtained from the plants in genus Physalis L. for the first time.