目的研究小花八角Illicium micranthum的化学成分。方法小花八角的枝叶提取物经醋酸乙酯萃取,余下水相经过反复的柱色谱分离、通过波谱分析确定化合物结构。结果分离得到了1个新化合物和9个已知的成分,分别是小花八角苷(1)、7-β-D-glucosyl pseudomajucin(2)、4,7,9-trihydroxy-3,3′-dimethoxy-8-O-4′-neolignan-9-O-α-L-rhamnopyranoside(3)、icariside E3(4)、isolariciresinol-3a-O-β-D-glucopyranoside(5)、芦丁(6)、杨梅树皮素-3-O-α-L-鼠李糖苷(7)、山柰酚-3-O-α-L-吡喃鼠李糖基-(1→6)-β-D-吡喃葡萄糖苷(8)、山柰酚-8-C-α-L-吡喃鼠李糖基-(1→2)-β-D-吡喃葡萄糖苷(9)、莽草酸(10)。结论化合物1为新化合物,是首次从八角属植物中分离到的seco-prezizaane型降倍半萜类化合物;化合物2～6为首次从该植物中分离得到。

ObjectiveTo investigate the chemical constituents of Illicium micranthum. Methods The extract from the twigs and leaves of I. micranthum was extracted with EtOAc and the H ₂O fraction was isolated by various chromatographic methods. The isolated compounds were identified by spectroscopic analyses. Results One new compound and nine known compounds were isolated and identified as micranthumoside (1), 7-β-D-glucosyl pseudomajucin (2), 4, 7, 9-trihydroxy-3, 3′-dimethoxy-8-O-4′- neolignan-9-O-α-L-rhamnopyranoside (3), icariside E3 (4), isolariciresinol-3a-O-β-D-glucopyranoside (5), rutin (6), myricetin-3-O-α- L-rhamnoside (7), kaempferol-3-O-α-L-rhamnopyranosyl-(1→6)-β-D-glucopyranoside (8), kaempferol-8-C-α-L-rhamnopyranosyl-(1→2)- β-D-glucopyranoside (9), and shikimic acid (10). Conclusion Compound 1 is a new nor-seco-prezizaane sesquiterpene first isolated from the plants in Illicium L. Compounds 2-6 are isolated from I. micranthum for the first time.

国家自然科学基金资助项目(31100256)