目的 制备赤芍总苷自微乳化给药系统（TGP-SMEDDS），优选其最佳处方，并对其进行初步的质量评价。方法 采用伪三元相图法优化自微乳化处方，并对最佳处方进行粒径、乳滴形态、Zeta电位、表面张力、自乳化时间、溶出度及稳定性评价。结果 由油酸乙酯、Cremophor RH40和Transcutol P组成的TGP-SMEDDS遇水可自发形成粒径为（47.26±0.08）nm的稳定微乳液，透射电镜下观察TGP-SMEDDS形态为均匀的球形，Zeta电位为（?22.80±0.42）mV。结论 制备的TGP-SMEDDS外观及稳定性良好，为赤芍总苷新剂型的进一步研究奠定了基础。

Objective To prepare the self-microemulsifying drug delivery system containing total glycosides in Paeoniae Radix Rubra (TGP-SMEDDS), optimize the formula, and preliminarily evaluate the quality. Methods The formula of self- microemulsifying was optimized with pseudo-ternary phase diagram. The droplet size and shape, Zeta potential, surface tension, self-microemulsifying time, dissolution, and stability were also evaluated. Results The TGP-SMEDDS composed of ethyl oleate, Cremophor RH40, and Transcutol P could spontaneously form a stable microemulsion with diameter about (47.26 ± 0.08) nm in water. TGP-SMEDDS presented uniform spherical drops under transmission electron microscope, and the Zeta potential was (?22.80 ± 0.42) mV. Conclusion The TGP-SMEDDS has good appearance and stability, which provides a strong foundation for the further research on new dosage forms of TGP.

辽宁省自然科学基金项目（20092015）；沈阳市科学技术计划项目（F10-205-1-28）；辽宁大学“211工程”三期建设项目